Proliferative Potential of Human Astrocytes
نویسندگان
چکیده
منابع مشابه
Proliferative potential of human astrocytes.
Although a number of studies have demonstrated proliferation of nonneoplastic astrocytes in experimental animal models, the proliferative potential of human astrocytes has not been well defined. Using double-label immunohistochemistry, we identified proliferating cells with the proliferation marker MIB-1 and astrocytes with glial fibrillary acidic protein staining in human biopsy and autopsy ti...
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Colony forming cells (CFC) with high proliferative potential have been detected in nutrient agar cultures of human bone marrow cells containing recombinant human interleukin-3 (IL-3) and granulocyte macrophage colony stimulating factor (GM-CSF). These CFC were detected by the formation of large colonies with diameters greater than 0.5 mm and containing approximately 50,000 cells after 28 days i...
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Glia affect neural circuits in numerous ways. Microglia strip synapses and clear debris after injury; oligodendrocytes form myelin, which regulates axon conduction velocity and limits sprouting; and astrocytes direct blood flow to active circuits, provide nutrients and growth factors, regulate extracellular ion concentrations, guide neurite growth, promote synaptogenesis, stabilize dendritic sp...
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ژورنال
عنوان ژورنال: Journal of Neuropathology & Experimental Neurology
سال: 2005
ISSN: 0022-3069,1554-6578
DOI: 10.1093/jnen/64.2.163